早期手术治疗对鼾症患儿智力发育的影响

目的 探讨早期手术治疗对鼾症患儿智力发育的影响,为小儿鼾症早期手术提供重要依据.方法 对鼾症患儿40例行双侧扁桃体和/或腺样体切除术（观察组）,采用中国-韦氏幼儿智力量表（C-WYCSI）进行术前和术后6个月的智力测试,包括语言智商和操作智商两部分共11项分测试;操作智商又包括视觉分析测验（VA）和几何图形测验（GD）两类.按照1∶1匹配选择同性别、同年龄（±3个月）、家庭条件相当的健康体检学龄前期儿童40例作为对照组进行比较.结果 观察组术前总智商、言语智商、操作智商分别为82、81、83,均低于对照组的101、101、101（t=4.131、3.952、3.842,均P＜0.05）;术后总智商、言语智商及操作智商分别为98、98、99,均在正常范围,与对照组差异均无统计学意义（均P＞0.05）.结论 鼾症患儿早期手术治疗可以改善患儿智力;鼾症患儿影响呼吸并有手术指征者,宜早期手术治疗.     

纳米碳对甲状腺手术中甲状旁腺的保护作用

目的：探讨纳米碳用于甲状腺手术中对甲状旁腺的保护作用。方法将72例患者随机分为两组各36例,对照组按甲状腺手术常规进行;观察组在甲状腺手术中,于甲状腺上下取2～5个点,在真被膜下方注入0．1～0．2 mL纳米碳混悬液,待甲状腺和周围淋巴组织染色后,完整游离甲状腺外科包膜,保护未染色组织,再常规行甲状腺手术。结果观察组术后发生低钙血症2例（5．6％）,对照组6例（16．7％）,两组差异有统计学意义（χ^2=13．87,P＜0．05）;观察组术后发生甲状旁腺功能减退1例（2．8％）,对照组为5例（13.9％）,两组差异有统计学意义（χ^2=14．53,P＜0．05）;观察组病理切片证实无误切甲状旁腺,对照组误切甲状旁腺7例（19．4％）,两组差异有统计学意义（χ^2=127．54,P＜0．05）。结论在甲状腺手术中使用纳米碳,可帮助鉴别淋巴结及甲状旁腺,从而降低甲状旁腺的损伤率。     

血清食物特异性IgG与慢性荨麻疹相关性研究

目的探讨慢性荨麻疹发病与血清中食物特异性IgG抗体的关系。方法应用酶联免疫吸附试验（ELISA）检测111例慢性荨麻疹患者（慢性荨麻疹组）血清中食物特异性IgG抗体水平,并与30例健康受试者（对照组）资料进行对比研究。结果111例慢性荨麻疹患者中,食物特异性IgG抗体阳性79例（阳性率为71．17％）,与对照组阳性率（43．33％）比较,差异有统计学意义（X2=8．071,P〈0．01）。且慢性荨麻疹组以鸡蛋特异性IgG抗体阳性率最高（51．35％）,其次是虾（43．24％）、牛奶（38．74％）、螃蟹（34．23％）、大豆（27．93％）,慢性荨麻疹组鸡蛋、虾、螃蟹、鳕鱼、大豆特异性IgG抗体阳性率与对照组比较,差异有统计学意义（P〈0．05）。结论食物特异性IgG抗体与慢性荨麻疹发病具有相关性,血清食物特异性IgG水平检测对慢性荨麻疹的预防和治疗具有重要意义。     

不同麻醉方式手术患者留置尿管时机选择比较分析

目的观察不同麻醉方式的手术患者留置尿管的最佳时间。方法将2011年1月至2014年1月该院收治的28例因外科手术需要留置尿管的患者,根据麻醉方式及导尿时机选择将其分为腰-硬联合麻醉前留置尿管（Ⅰ前组）、腰-硬联合麻醉10 min后留置尿管（Ⅰ后组）、全身麻醉前留置尿管（Ⅱ前组）、全身麻醉10 min后留置尿管（Ⅱ后组）共四组,各7例。收集、分析相关数据,比较四组患者插管时心率、血压、并发症等各项指标。结果不同麻醉方式麻醉10 min后留置尿管,患者插管前后心率和血压比同种床醉方式麻醉前留置尿管稳定,且患者舒适度好、并发症少,差异均有统计学意义（P〈0.05）。结论无论是腰-硬联合麻醉还是全身麻醉的手术患者,留置尿管的最佳时间均为麻醉10 min后。     

陕西省宝鸡市居民膳食营养与慢性病关系调查分析

目的 了解陕西省宝鸡市居民膳食营养相关情况,为制订相关慢性病防控措施提供科学依据.方法 采用抽样调查、半定量食物频率调查法和营养成分分析等方法进行调查.结果 共调查5 020人.陕西省宝鸡市居民对蔬菜类、水果类、鱼虾类、奶类等摄入量不足,分别为平均每人每天摄入213.5、126.8、5.2、50.7 g,而对食用油和盐摄入量超标,分别为52.6、9.5 g;不同性别对谷类、蔬菜类、豆类、奶类、油等摄入量比较,差异均有统计学意义（P〈0.05）,城市与农村比较,除油外,其余差异也均有统计学意义（P〈0.05）;对维生素A、B2、B6和叶酸、钙等摄入量明显不足,对钠摄入量显著超过推荐量,不同性别对营养素摄入量比较,差异也有统计学意义（P〈0.05）;居民中超体质量者占27.0%,肥胖者占5.4%.结论 应提倡居民增加蔬菜类、水果类、鱼虾类、奶类等食物的摄入,限制油和盐的摄入,通过合理膳食防控高血压、糖尿病等相关慢性病的发生.     

复方斑蝥胶囊联合同步放、化疗在宫颈癌治疗中的临床疗效观察

目的：观察宫颈癌同步放、化疗联合复方斑蝥胶囊的临床疗效。方法将经病理检测证实的宫颈鳞癌患者108例分为观察组54例（给予同步放、化疗联合复方斑蝥胶囊治疗）和对照组54例（给予单纯同步放、化疗治疗）。观察治疗后患者发生骨髓抑制、乏力及盗汗等放、化疗相关不良反应情况。结果观察组骨髓抑制、乏力、盗汗发生率分别为79.6%（43/54）、16.7%（9/54）、24.1%（13/54）,对照组分别为96.3%（52/54）、64.8%（35/54）、55.6%（30/54）,两组比较,差异均有统计学意义（χ2=7.083、25.926、11.167,P＆lt;0.05）。结论宫颈癌同步放、化疗联用复方斑蝥胶囊可有效减少不良反应的发生,保证治疗过程的顺利进行。     

Effect of Morinda citrifolia fruit extract and its iridoid glycosides on blood fluidity

The aim of this study was to investigate the effect of Morinda citrifolia fruit on blood fluidity. M. citrifolia fruit extract (MCF-ext) was investigated for its influence on blood aggregation and fibrinolysis. MCF-ext inhibited polybrene-induced erythrocyte aggregation and thrombin activity. The fibrinolytic activity of MCF-ext, in the euglobulin lysis time test and fibrin plate assay, is reported here for the first time. One of the active compounds was an iridoid glycoside, asperulosidic acid. The results indicated that MCF-ext is a potentially useful health food which is capable of improving blood flow and preventing lifestyle-related diseases.     

In vitro cytotoxicity,cell cycle arrest,and antioxidation studies of ruthenium(II) complex [Ru(dmb)2(AHPIP)](ClO4)2

A new Ru(II) complex [Ru(dmb)₂(AHPIP)](ClO₄)₂ (Ru1) was synthesized and characterized by elemental analysis, electrospray ionization mass spectra, and ¹H NMR and ¹³C NMR. The cytotoxicity in vitro toward BEL-7402, HeLa, MCF-7, and MG-63 cells was studied by MTT method. The complex shows moderate cytotoxic activity and the IC₅₀ values are 20.2 (±1.6), 16.8 (±1.3), 39.9 (±2.5), and 46.7 (±2.0) μM toward BEL-7402, HeLa, MCF-7, and MG-63 cell lines, respectively. Apoptosis was studied by acridine orange/ethidium bromide staining and flow cytometry. The cellular uptake showed that the complex can enter into the cytoplasm. The cell cycle arrest showed that Ru1 inhibits the proliferation of BEL-7402 cells in the G0/G1 phase. In addition, the antioxidant activity of the complex against hydroxyl radical (^·OH) was also investigated.     

Synthesis and biological evaluation of novel quinolin-2(1H)-one derivatives as potential antimicrobial agents

A series of novel quinolin-2(1H)-one derivatives were synthesized and characterized by IR, ¹H NMR, ¹³C NMR, and MS spectral data. All the new compounds were screened for their antimicrobial activities against six trains of bacteria and five fungi in vitro by twofold serial dilution technique. The bioactive assay showed that most of the compounds exhibited moderate to good antimicrobial activities in comparison with the streptomycin, especially, compound 6a, the fluoro-substituted aromatic amide derivative, showed good antibacterial activities against B.proteus and P.aeruginosa with minimal inhibitory concentration value of 32 and 16 μg/ml, respectively.     

Studies on the inhibitory models of pyrazoline derivatives as EGFR kinase inhibitors by 3D-QSAR and molecular docking

The development of EGFR kinase inhibitors attracts much attention of research for treating of cancer in recent years. In this work, based on a dataset composed of 46 EGFR kinase inhibitors, the combination of three-dimensional quantitative structure–activity relationship (3D-QSAR), molecular docking was applied to reveal structural characteristics impacting the inhibitory activity of EGFR, and to provide a better understanding of the binding modes between inhibitors and EGFR kinase. 3D-QSAR models of pyrazoline derivatives were established to reveal how steric, electrostatic, hydrophobic, and H-bond acceptor interactions contribute to inhibitors’ bioactivities, which were unanimous in the docking results. Furthermore, based on the most active compound, several new molecules with high inhibitory activity were obtained.